Whas the name of this horror movie from the 80's?

Okay I vaguely remember there is a couple in it and the husbands obsessed with being in his dungeon like basement so something happens and his wife leaves the home and falls in love with an investigator guy who starts investigating what's in the guys basement. There's something about this sacred book about re animation and stuff and a flashback to like the medieval age where a scientist created an "abomination" and they cast it down the river in a storm and some people found it.. it was like all gnarly and mangled looking a mess of ugly skin and bones like half a body and it was alive. So in the end the investigator guy find out the scientist guy has abomination creatures he'd been making in his basement dungeon and he fights them and therer is this really nasty lookin one he fights. Then he uses like some magical thing like some bones or something to defeat the mad scientist and then the mad scientist gets thrown in the crazy hospital and is haunted by the bones or crazy **** he created. Any one know the name of this movie?